We found that modulation of iron levels directly influences myotube size in vitro and muscle mass in otherwise healthy mice. In this study, we discovered strong alterations of iron metabolism in the skeletal muscle of both cancer patients and tumor-bearing mice, characterized by decreased iron availability in mitochondria. Knowledge regarding the mechanism of cancer-induced cachexia remains very scarce, making cachexia an unmet medical need. Tel: +39 0116706422 E-mail: Ĭachexia is a wasting syndrome characterized by devastating skeletal muscle atrophy that dramatically increases mortality in various diseases, most notably in cancer patients with a penetrance of up to 80%. These authors contributed equally to this work as senior authors These authors contributed equally to this work as first authors 10 Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), University of Antwerp, Antwerp, Belgium.9 Department of Medical Oncology, University Hospital Antwerp, Edegem, Belgium.
4 Department of Clinical and Biological Sciences, University of Torino, Turin, Italy.3 Department of Surgical, Oncological and Gastroenterological Sciences, Padova University Hospital, Padova, Italy.2 Department of Biomedical Sciences, University of Padova, Padova, Italy.1 Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Turin, Italy.
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